5-chlorothiazolo[5,4-b]pyridin-2-amine

5-chlorothiazolo[5,4-b]pyridin-2-amine - Names and Identifiers

Name	5-chlorothiazolo[5,4-b]pyridin-2-amine
Synonyms	o[5,4-b]pyridin-2-amine 5-chlorothiazolo[5,4-b]pyridin-2-amine 5-CHLORO-THIAZOLO[5,4-B]PYRIDIN-2-AMINE 5-Chloro-thiazolo[5,4-b]-2-aMinopyridine Thiazolo[5,4-b]pyridin-2-amine, 5-chloro- thiazolo[5,4-b]pyridin-2-amine, 5-chloro- 5-Chloro[1,3]thiazolo[5,4-b]pyridin-2-amine 5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-aMine
CAS	31784-71-1
InChI	InChI=1/C6H4ClN3S/c7-4-2-1-3-5(10-4)11-6(8)9-3/h1-2H,(H2,8,9)

5-chlorothiazolo[5,4-b]pyridin-2-amine - Physico-chemical Properties

Molecular Formula	C6H4ClN3S
Molar Mass	185.63
Density	1.632±0.06 g/cm3(Predicted)
Boling Point	356.8±45.0 °C(Predicted)
Flash Point	169.6°C
Vapor Presure	2.85E-05mmHg at 25°C
pKa	0.81±0.40(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.781

5-chlorothiazolo[5,4-b]pyridin-2-amine - Introduction

5-chlorothiazolo[5,4-b]pyridin-2-amine is an organic compound with the chemical formula C7H5ClN4S. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 5-chroothiazolo [5,4-b]pyridin-2-amine is a white to light brown solid.
-Solubility: It is almost insoluble in water, but can be dissolved in organic solvents (such as ethanol, chloroform).
-Melting point: Its melting point range is 162-165 ° C.
-Stability: 5-cholothiazolo [5,4-b]pyridin-2-amine is relatively stable at room temperature.

Use:
-Chemical reagent: It can be used as a reagent in organic synthesis and is often used to synthesize other organic compounds.
-Drug research: Due to its special structure, 5-chlorothiazolo[5,4-b]pyridin-2-amine can be used as an intermediate for drug research and used to synthesize active compounds.

Method:
The preparation of 5-chroothiazolo [5,4-b]pyridin-2-amine can be carried out by a variety of methods. The following is a typical preparation method:
-5-Chlorothiazolecarboxylic acid is reacted with hydrogen chloride to obtain 5-chloro-2-aminothiazole.
-5-chloro-2-aminothiazole reacts with pyridine and cyclizes under acid catalysis to obtain 5-chlorothiazolo[5,4-b]pyridin-2-amine.

Safety Information:
-5-cholothiazolo [5,4-b]pyridin-2-amine has no obvious danger under general conditions of use.
-Use should comply with the correct experimental practice and safety precautions.
-Wear appropriate protective equipment such as lab gloves, goggles, etc. when handling the compound.
-Avoid inhaling its dust or solution in contact with skin, eyes and mouth. In case of accidental contact, rinse the affected area immediately with plenty of water and seek medical help.
-Avoid contact with chemicals such as oxidants or strong acids to prevent dangerous reactions.
-Store and dispose of the compound properly in accordance with local regulations.

Last Update：2024-04-09 15:17:56